I often like to draw starting from the gray scale to better see the lights and shadows. and then the color.
but I have a question that I can’t explain.
Why CMYK color mode, does not have color blending modes in layers??
to overcome this I have to convert to RGB and then again to CMYK
I’m not the best to describe it, but in the end it has to do with mathematics, you can not perform every calculation on CMYK that RGB allows, and since computer graphics is math under the hood, and every blending needs calculations, it can be that you can use it with X but not with Y.
But usually it is a good idea to always work in RGB and use softproofing during the process to check if it looks okay in your target colorspace, and when you are ready you can convert it to CMYK.
Furthermore, you can tie your color selector to CMYK so you paint in RGB but select only CMYK compatible color.
Let’s see what @Takiro says about it.
Michelist
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Most Blending Modes don’t work in non RGB (or are inverse) simply because the math does not work out. Other software solves this by only using RGB in the background and pretending to be CMYK (or whichever the user wants). I believe it is to imprecise and a overhead so Krita simply currently doesn’t do this.
It’s probably possible to implement the Blending mode for CMYK too but no one has simply done this for Krita because of either staff or monetary constrains. I can only guess why no one has volunteered to do this.
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Having to work on a project that will go to print.
I immediately set CMYK.
But once the work started I noticed this thing.
I was initially calling all saints.
Then I decided to do this test of converting to RGB and then once the job was finished again to CMYK and I solved it.
But I didn’t know about this thing about mathematical calculations.
In fact I noticed that many blending modes in CMYK were not present in RGB.
Now I know.
Thanks to both of you. 
It would be a good idea to read up the following part of Krita’s manual:
and especially this subpart of it:
Michelist
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Are you sure this is the right thing to do, because the print shops I worked with in recent years all don’t even want CMYK files anymore, they either want RGB or have their own Color Profile you need to proof against. Normally nowadays you work in RGB only, use soft proofing to check your stuff in CMYK (you can set up soft proofing in Krita) color space and only convert right at the end (or not).
We actually have many topics about this on the forum, this is one of them:
One of the reason is that industry printers don’t even work on CMYK anymore, they often have more than 12 different colors to make up for the colors CMYK can only mix badly.
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many thanks takiro.
Actually I always work in RGB and then convert.
More than anything for the choice of color range.
CMYK is very limited and doesn’t allow me to have those lights and tones that only RGB can give you.
But I have always thought that when printing it was better to start in CMYK.
This topic you posted gave me a lot of very useful information that I didn’t know.
Many thanks again Takiro.
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This topic came up here often enough and you can find many professionals replying to them. CMYK probably still is good when you print on an office printer that still actually has CMYK. But professional print shops and their printers don’t really use that anymore for art prints at least. It is also dependent on the kind of print used (offset and what not). Normally you ask the printer (the person) for what they want but usually they just want RBG and sometimes can give you a print profile you can import into Krita and use for soft proofing. Another issue with changing colors to CMYK is that your display is most likely not calibrated to it (Krita tries to convert the colors the best it can for tje display) and at the end the print looks different anyway.
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