Here are some thoughts:
-in Krita toggle view->full screen mode (set a hotkey)
-set the Windows taskbar to auto-hide (right click taskbar->settings->“Automatically hide the taskbar in desktop mode”)
-increase auto-save frequency
scripts:
-set toolbars to be non-movable
-hide/disable the menu
-hide/disable specific actions: quit, settings, toolbar config, etc
A hotkey would be able to toggle such things on and off.
plugin/script
-a big/obvious button that ensures all relevant stuff is “reset” (but not the document)
plugins:
-disable docker resizing (see the script)
-hide docker titlebar
These two plugins will hide the titlebars and lock resizing by default, there is a constant at the start of each file that can be set to False. I’ve not got mine set as hotkeys, i have a button on a toolbar. You could do that and then hide that partiular toolbar.