Krita Version: 5.2.2, Windows 10. When working with the brush tool on an image in 32 bit color space, I notice a significant difference in the speed of building up of color saturation / opaqueness or rate of flow of color depending on the brightness of the applied color. Bright colors build up fast, dark colors build up slow. Best noticeable when working with white and black with an airbush and with the airbrush option enabled, with a Wacom tablet, flow and airbrush option (constant flow of color) both set to pen pressure in brush tool settings. This problem is nonexistent in 8 bit color space and highly obvious when working in 32 bit color space.
Does the situation improve if you use version 5.2.3?
Could your computer be regarded as ‘reasonably powerful’?
I have installed and work with 5.2.2 , I have not tried out 5.2.3 yet.
My PC is ‘reasonably powerful’ as it was specifically build for digital painting and handling large image files.
I just downloaded and installed version 5.2.3 and the problem is still exactly the same. A brush stroke with black is almost not noticeable, with white the color shoots out of the brush tool. Both behaviors for bright and dark colors are anomalous when compared to the exact situation in 8 bit color space, where the brush behavior for bright and dark colors is identical and not depending on color brightness. Btw, the background color you are working on is irrelevant, it happens on bright, middle-bright and dark background color.
This topic comes up somewhat regularly, it’s most likely just the difference between sRGB TRC and linear RGB color blending you’re seeing there.
If you pay attention to the color profile when creating a new document, you’ll noticed that anything above 8 bits/channel defauls to the sRGB-elle-V2-g10.icc profile instead of the sRGB-elle-V2-srgbtrc.icc profile.
Nothing stops you from using the profile with sRGB TRC for higher bit depths though, you just need to explicitly select it.
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@Lynx3d You are my savior! Seriously, you have relieved me of a lot of distress! You were right, thank you so much! 
So, Krita version 5.2.3 just froze / hung itself up when I tried to close it. That never happened with version 5.2.2 when I was using it during the past 1,5+ months. I guess I’ll stick for the moment with version 5.2.2 until these main bugs in 5.2.3 are fixed to a significant degree…
Plus, my Wacom tablet driver was just screwed up a few minutes ago and I had to install it anew. I don’t know if that was just pure coincidence or if it had actually something to do with installing, trying out and then de-installing Krita version 5.2.3.
Well, now I re-installed Krita version 5.2.2 and also my tablet driver and everything seems to work fine again… 
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