How to fully customize Krita's UI colors? (Themes or Plugins?)

There are plugin that will change the appearance of the UI.
The simplest way to change the ‘cosmetic’ appearance, i.e. the colours, is to download and use a ‘theme’ file.

Please read this topic: Zoldyako's Themes for Krita v2
And this one: Krita themes - changing stuff

If you use the forum Search to look for ‘themes’ then you’ll find lots of topic on the subject, especially if you look in the Resources category:
Search results for 'theme #resources' - Krita Artists