You can tick off this option and try if the lag presist.
It it’s no use, there maybe something not related to OpenGL, but I have no knowledge about Mac
Related old post
Krita lag fix for Macs:
Go to Settings>Configure Krita
If Configure Krita is not an option under the settings bar, go to Settings>Configure Toolbars>mainToolBar and scroll down until you see “Configure Krita” in the lefthand side. Select “Configure Krita” and press the right arrow key in the middle of the window, or drag “Configure Krita” into the left hand side. Make sure you click “Apply” before “OK”. Now you will see in the top lefthand side of your Toolbar a new tool that looks like this:
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